Poly (neutral) Lite Avidin

Garantee of highest signal intensity

As Supplier, e-Proteins guarantees the best prices for the highest quality.

Our customers working with the cross linking streptavidin technology have requested to e-Proteins to develop a new product with the Neutralite avidin’s advantages combined with the cross-linking streptavidin high sensitivity. 

After more than five years of research, e-Proteins has implemented a innovative process that enables to produce a Poly-neutralite avidin with a profile presenting a higher level of dimers, trimers and quadrimer comparing the the cross-linking steptavidin profile.  This innovative product is ready to use ! 

In vitro diagnostics (IVDs) is at constant search for more specificity which – in practical terms – melts down to tracking for higher signal / background ratio. Neutralite Avidin – carrying a nearly neutral charge, no oligomannosidic glycan and no Arg-Tyr-Asp (RYD) amino acids sequence – has served that specific purpose for quite some years through reducing background or non-specific bio-recognition by some 75%.

With Poly (or Oligomerized) (Neutra) Lite Avidin, e-Proteins goes one step further in increasing the intensity of the signal by some 133%, leading to an overall improvement of min 500% in specificity in comparison to the original avidin. A unique approach to high performance IVD, direct substitution, no brainer!

Product competitor : Cross-linking streptavidin , “Polystreptavidin R”

Poly neutraLite Avidin, polymerized bing proteins , streptavidin polymerized

.                    normal coating with                Dimer coating                          Trimer coating
.                    1 binding layer                        with 2 binding layers               with 3 binding layers
.                                                                     signal increase : + 50 %           signal increase : + 130 %

Prices

ProductQuantityPrice DimerPrice trimerorder
Poly Lite Avidin (PLA)
100 mg1 310 €1 820 €
Poly Lite Avidin (PLA)1 gr10245 €14 230 €
Poly Lite Avidin (PLA)10 gr92 736 €128 800 €
Poly Lite Avidin (PLA)100 gr 777 600 €1 080 000 €
Poly neutral Lite Avidin (PnLA)
100 mg1572 €2184 €
Poly neutral Lite Avidin (PnLA)1 gr12 290 €17075 €
Poly neutral Lite Avidin (PnLA)10 gr111 283 €154 560 €
Poly neutral Lite Avidin (PnLA)100 gr 933 120 €1 296 000 €

Specifications

PhysicochemistryPLA DimerPLA TrimerPnLA DimerPnLA Trimer
Purity100%100%100%100%
Activity
(U/mg solid)
> 14> 14> 13> 13
Moisture content
(% w :w)
< 5.0 %< 5.0 %< 5.0 %< 5.0 %
Extintion coefficient1.80-2.001.80-2.001.80-2.001.80-2.00
Isoelectric point9,5 ± 0,29,5 ± 0,26,2 ± 0,26,2 ± 0,2
Deglycosylation level± 90%± 90%± 90%± 90%
Dimer > 10%OKOKOKOK
trimer > 3%N/AOKN/AOK
Optimum Solubility
(transmittance @650nm
15mg/ml in water pH)
pH < 7 and pH > 10 pH < 7 and pH > 10 pH < 5 and pH > 8 pH < 5 and pH > 8
MicrobiologyPLA and PnLA
Total Bacterial Count in 1 mg< 1
OtherNAP100
Definition of
activity
One Unit activity binds

1 µg of biotin
Country of
Manufacturing
Belgium
OriginEgg proteins from hens
ApparenceWhite to off white free
flowing lyophilised
powder, free of any
visible impurities

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