Poly (neutral) Lite Avidin
Garantee of highest signal intensity
As Supplier, e-Proteins guarantees the best prices for the highest quality.
Our customers working with the cross linking streptavidin technology have requested to e-Proteins to develop a new product with the Neutralite avidin’s advantages combined with the cross-linking streptavidin high sensitivity.
After more than five years of research, e-Proteins has implemented a innovative process that enables to produce a Poly-neutralite avidin with a profile presenting a higher level of dimers, trimers and quadrimer comparing the the cross-linking steptavidin profile. This innovative product is ready to use !
In vitro diagnostics (IVDs) is at constant search for more specificity which – in practical terms – melts down to tracking for higher signal / background ratio. Neutralite Avidin – carrying a nearly neutral charge, no oligomannosidic glycan and no Arg-Tyr-Asp (RYD) amino acids sequence – has served that specific purpose for quite some years through reducing background or non-specific bio-recognition by some 75%.
With Poly (or Oligomerized) (Neutra) Lite Avidin, e-Proteins goes one step further in increasing the intensity of the signal by some 133%, leading to an overall improvement of min 500% in specificity in comparison to the original avidin. A unique approach to high performance IVD, direct substitution, no brainer!
Product competitor : Cross-linking streptavidin , “Polystreptavidin R”
. normal coating with Dimer coating Trimer coating
. 1 binding layer with 2 binding layers with 3 binding layers
. signal increase : + 50 % signal increase : + 130 %
|Physicochemistry||PLA Dimer||PLA Trimer||PnLA Dimer||PnLA Trimer|
|> 14||> 14||> 13||> 13|
(% w :w)
|< 5.0 %||< 5.0 %||< 5.0 %||< 5.0 %|
|Isoelectric point||9,5 ± 0,2||9,5 ± 0,2||6,2 ± 0,2||6,2 ± 0,2|
|Deglycosylation level||± 90%||± 90%||± 90%||± 90%|
|Dimer > 10%||OK||OK||OK||OK|
|trimer > 3%||N/A||OK||N/A||OK|
|Optimum Solubility |
15mg/ml in water pH)
|pH < 7 and pH > 10||pH < 7 and pH > 10||pH < 5 and pH > 8||pH < 5 and pH > 8|
|Microbiology||PLA and PnLA|
|Total Bacterial Count in 1 mg||< 1|
|Definition of |
|One Unit activity binds
1 µg of biotin
|Country of |
|Origin||Egg proteins from hens|
|Apparence||White to off white free
powder, free of any